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With 2x 4pot calipers, I'd be going for the 19mm, to make sure you get enough fluid pumped.
The RCS arrangement (as described in Luddite's link) will effectively allow you to dial in more 'feel'.
FWIW, I have a 19x18 fixed ratio radial MC on one of my bikes, with twin 4pot goldline calipers and it's fine although you'll never really need more than one finger on the lever.
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