I have an M600 and an S2R (expect my son to be along at some point correcting me!!) I much prefer the S2R for a few reasons:
It's fuel injected
The 800 engine has more grunt
It's clutch is so light
It's great around town (I commute on it)
It's fun on long journey's
It's a good all rounder whereas my M600 was very temperamental
At the end of the day though everyone loves their bike for their own reasons